I'm in my late 40s, single, own a house independently, responsible for all my own expenses.
I've definitely gotten way less conservative as I age. I don't rage at paying taxes because I want my neighbors to have nice roads and schools and healthcare and food and food educations even if they're poor, even if they're immigrants. Because that's what Jesus world want me to do with my money: provide for my neighbor.
No, they do not have different drug trials based on sex or gender. No, medication absolutely does not have different effects based on sex or gender. Hearts, lungs , kidneys, all work the same no matter what kind of reproductive organs you happen to possess.
We do not distinguish based on sex or gender when administering medications. We only account for body size and individual response/tolerance to a medication.