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Popular gut probiotic completely craps out in randomized controlled trial (arstechnica.com)

submitted 1 month ago by DocMcStuffin@lemmy.world to c/health@lemmy.world

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In a randomized controlled trial, the probiotic Bifidobacterium animalis subsp. lactis—used in many probiotic products, including Dannon's Activia yogurts—did nothing to improve bowel health in people with constipation, according to data from a randomized triple-blind placebo-controlled clinical trial Wednesday in JAMA Network Open.

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[–] MaximilianKohler@lemmy.world 12 points 1 month ago (1 children)

Stomach acid is meant to kill anything, whether it’s a pathogen or beneficial probiotic. Yogurt’s probiotics shouldn’t survive the stomach if all is going well.

This is misinformation.

I had SIBO

Not likely. https://humanmicrobiome.info/sibo/

You're getting your information from poor quality sources.

I eventually took a double capsule probiotic designed to survive the stomach intact and open in the small intestine and my symptoms were mostly resolved within a week.

Almost certainly placebo or random luck. There are a plethora of probiotic and FMT studies that show it can have significant impacts when you take it directly orally:

We are just starting to understand how crucial gut health is to overall health, including mental health, and basically everyone gets their gut biome carpet bombed with antibiotics on the regular.

Agree. I've done FMT from 15+ donors and haven't yet reversed the damage from antibiotics. When I would share studies about this on reddit I would get viciously attacked by people who seemed addicted to antibiotics.

[–] picnicolas@slrpnk.net 8 points 1 month ago

I appreciate you sharing this information. What you’ve shared seems accurate to our current scientific consensus. You’re right that some probiotics and pathogens survive the stomach.

Honestly I did my best to research my condition but my mind was functioning quite poorly at the time and most doctors were of no help. Once I got better I may have drawn an inaccurate conclusion as to why the prior probiotics I had taken hadn’t helped whereas this one (Seed) worked so miraculously. It could simply be that the strains in that particular probiotic helped rebalance things for me whereas everything I had tried prior were not what I needed. Maybe those particular strains my gut was needing don’t survive the stomach environment well.

The probiotic that resolved my symptoms almost certainly was not placebo. That I was lucky I can agree with.

I’m sorry you’re still trying to heal your gut despite your thorough knowledge and FMT. It’s been a few years I’ve felt mostly better but I still don’t have the energy levels I did.

Antibiotics are miraculous but not a panacea and are definitely overprescribed and used unjudiciously in livestock.

I wish you the best on your healing journey. Thanks for sharing good information.