it must be comforting to think that there's some bigger plan, and they can't possibly be this stupid and incompetent
(by now i do think that they're this stupid and incompetent, and if it appears that there's no plan going forward it is because there was never one. they're malicious, see Zelensky visit, and can plan perhaps a week in advance, but nowhere near sophisticated enough to come up with this)
I'm with the old man on this one. Antibodies can clear out amyloid and still it has no effect on progression of disease, amyloid secretion can be blocked upstream (like with small molecule protease inhibitors) and it still has no effect. Maybe this one hits something off-target, or maybe that effect is not even real, or maybe it's some sort of statistical artifact. You'd stumble upon some false positive after trying so many times.
Aducanumab is dead in the water, trials shown no effect and it was abandoned by Biogen. This one is about lecanemab. Both have massive problems with brain edema and microhemorrages, which probably means these are not suitable for actual use. But don't worry, they already have received their reward - FDA wanted to have something, anything to show up for Alzheimer and Biogen cashed in when stock price went up
think cold fusion, or EmDrive, or string theory
That's a weird set - cold fusion or EmDrive can be tested and their physical principles are falsifiable - and they were - but string theory is different, because it's not falsifiable.
If it’s marginally but truly effective,
That if makes some mighty heavy lifting here. I think that amyloid hypothesis is closer to cold fusion than to string theory in that it had already a couple of fatal experimental refutations thrown at it, but people still shove effort this way because there's nothing else/copium/sunk cost combination
perun weighs in on tariffs and guesses what might come next https://www.youtube.com/watch?v=nVZ1lcw2bVU
some things perun notes that i hadn't because i haven't followed the entire situation closely: that trade deficit calculation uses goods only, not services, and this is most of what sv exports; eu might retaliate against sv oligarchs specifically. also we're in times where it's necessary to pull up american govt pages from internet archive to make a point. fun. also chatbot-cooked policy looks suspiciously like chatbot solution to a entry level econ course toy problem with loads of very unusual assumptions, which are discussed too.
maybe stable genius tries to bring american wages closer to global average