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The quest for a longer-lasting whooping cough vaccine (www.bbc.com)

submitted 3 weeks ago by MicroWave@lemmy.world to c/health@lemmy.world

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Summary

Whooping cough, a highly contagious respiratory illness, is resurging globally due to waning vaccine effectiveness and declining vaccination rates.

Current acellular vaccines, widely used in wealthier nations, lose potency after 5-10 years, leaving teens and adults vulnerable.

Emerging third-generation vaccines, like BPZE1, show promise for longer-lasting immunity by targeting nasal mucosal immunity, which existing injections lack. Nasal vaccines and innovations like outer-membrane vesicles could improve protection.

However, challenges remain, including funding, vaccine hesitancy, and pharmaceutical incentives favoring multi-dose regimens over long-lasting solutions.

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