this post was submitted on 22 Sep 2024
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D-phenylalanine (enkephalinase inhibitor)

Interesting substance, its one of the few dextro (right-spinning optical isomer) amino acids that you can process or something.

I think its fascinating because its purportedly an ~~endorphin reuptake~~ enkephalinase inhibitor? or something so its potentially quasi-opioidergic. I'm not sold on the notion its legit but its definitely a provocative idea.

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[–] intensely_human@lemm.ee 17 points 1 month ago (1 children)

Glutamate is good to know about.

It’s the oldest intercellular signaling chemical in evolutionary history. Sponges use glutamate to communicate between cells, so it predates nervous systems.

It has tons of distinct meanings in the human body’s context, but mostly it means “fight or flight”. A state of excessive glutamate signaling, sometimes referred to as a “glutamate storm”, is associated with feelings of overwhelm and panic attacks.

It can be blocked from binding by a chemical called L-theanine, which occurs naturally in tea and can be bought in pills at supplement stores. Studies have shown that people who take L-theanine supplements experienced reduced beta wave amplitude and increased alpha wave amplitude.

In my own experience, L-theanine pills can basically nullify the “frozen” feeling I have with procrastinating on complex work, such as homework or software development, or even just complex decision-making.

In other words, it’s the most effective anti-procrastination substance I’ve ever encountered. This is compared with:

  • anti-anxiety meds like xanax
  • blood pressure meds like propranolol
  • more coffee
  • adderall
  • ritalin
  • cocaine
  • alcohol
  • antidepressants
  • microdosed LSD
  • microdosed psilocybin
  • pseudoephidrine
  • maca

… all taken at once. Not recommended

[–] whatwhatwhatwhat@lemmy.world 2 points 1 month ago (1 children)

all taken at once

I beg your finest pardon. That’s my secret recipe to success.

+1 for L-theanine though, it’s one of my favorite supplements. Although, more than once I’ve had to explain to someone that it’s not a Spanish word (“el theanine”).

[–] intensely_human@lemm.ee 1 points 1 month ago (1 children)

Of course. In Spanish it’s el teanino

[–] cheese_greater@lemmy.world 1 points 1 month ago

Wouldn't it be el L-teanino? Haha

[–] Corno@lemm.ee 12 points 1 month ago* (last edited 1 month ago) (1 children)

Tryptophan. It is a biochemical precursor for important neurotransmitters, vitamins and hormones such as melatonin, serotonin, and niacin. There happens to be very high concentrations of it in milk and eggs, both of which I love a lot. It can have sedating effects and make you feel chilled out!

[–] RBWells@lemmy.world 3 points 1 month ago

I am a fan of tryptophan!

[–] simplymath@lemmy.world 9 points 1 month ago (1 children)

MSG because it's delicious.

[–] palordrolap@fedia.io 3 points 1 month ago (1 children)

This feels like one of those "is water wet?" pseudo-paradoxes.

Is MSG actually tasty or does it make other things tasty while not actually being tasty itself?

[–] simplymath@lemmy.world 3 points 1 month ago (1 children)

definitely A. Eat a big spoonful sometime.

[–] palordrolap@fedia.io 2 points 1 month ago (1 children)

The video of the soon-to-be-very-disappointed kid eating a spoonful of drinking chocolate powder just played in my head. And oh, there goes a cinnamon challenge one as well.

I think I'll pass.

[–] simplymath@lemmy.world 3 points 1 month ago

no, no. I promise you that it's delicious. it's like biting into a ball of miso.

[–] Boozilla@lemmy.world 8 points 1 month ago

Public schools and religious college failed me. I do not have a favorite amino acid.

[–] RobotToaster@mander.xyz 8 points 1 month ago (1 children)

Probably plain L-phenylalanine, since it's the precursor to phenethylamine, the body's natural amphetamine.

[–] cheese_greater@lemmy.world 2 points 1 month ago

Have you taken l- or dl-phenylalanine?

[–] Ozymandias1688@feddit.org 8 points 1 month ago

Cysteine, because it makes proteins stable.

[–] OlinOfTheHillPeople@lemmy.world 7 points 1 month ago

Glutamine makes mouths happy!

[–] Zerlyna@lemmy.world 6 points 1 month ago (1 children)

Tryptophan because it helps you be happy and sleepy.

[–] superkret@feddit.org 5 points 1 month ago (1 children)

Is that what the brain makes after sex?

[–] ArtieShaw@fedia.io 3 points 1 month ago (1 children)

I think you get it from eating turkey.

[–] cheese_greater@lemmy.world 2 points 1 month ago* (last edited 1 month ago)

...After-sex turkey

[–] lemmur@szmer.info 6 points 1 month ago

Metionine, because everything starts of it.

[–] philo@lemmy.ca 6 points 1 month ago

As a pirate, my favorite amino acid is arrrrr-genine 😁

[–] ArbitraryValue@sh.itjust.works 6 points 1 month ago

Alanine. No baroque ornamentation, just the beauty of simplicity. A timeless classic.

[–] Shadow@lemmy.ca 5 points 1 month ago (1 children)

Lysine, because ingen tried to use it to control dinosaur populations.

[–] Reverendender@sh.itjust.works 2 points 1 month ago

I also give it to my cats for immune support

[–] whotookkarl@lemmy.world 4 points 1 month ago

https://youtu.be/Fn0jhDEtEGI

Because surf rock aliens with a theremin are awesome

[–] AmidFuror@fedia.io 3 points 1 month ago

Proline because it's kinky.

[–] HubertManne@moist.catsweat.com 3 points 1 month ago (1 children)

glycine. so if anyone is aware of cron there was a study which showd methionine restriction seemed to have a similar effect and a further study that glycine which helps eliminate glycine to do so as well as a supplement. Mouse studies though (not cron which has more data but the others are like one study each last I saw.)

[–] cheese_greater@lemmy.world 1 points 1 month ago (1 children)
[–] HubertManne@moist.catsweat.com 2 points 1 month ago

calorie restriction with optimal nutrition. walford used it when an emergency happened in biosphere and its been done up to monkey levels so its pretty well studied. He was following it himself but died to a genetic disease.

[–] Pulptastic@midwest.social 2 points 1 month ago

Leucine for dem gains