Programming

I'm a fan of early returns.
So

if(isalpha(letter) == false) return letter
if(letter whatever) {
   Do thing
   Return letter
}
if(letter something else) {
   Do something else
   Return letter
}
throw error("unprocessable letter")

I find it lets me mentally walk through all the paths more easily.
And if something gets too complex for this, then I need to break it down into further functions

I second the early return suggestions, but the other thing you should be aware of is that isalpha() is being evaluated twice unnecessarily. If its cheap and not call frequently, not a real big problem, but it is a waste of cycles. If you want to document the else, you could try:

...
}
else  // isAlpha() == false
{
...

Also, if isAlpha was something that could change between evaluation, such as isTuesday, you are at risk of the first call returning false, and then the second call returning true, which would skip both cases.

you are checking the result of a method that returns a boolean (true/false) there is no reason to check for true, else, FILE_NOT_FOUND. you can also forgo equating its return value to something to get a boolean value required for the if statement since its already a boolean value.

e.g.

if (isalpha(letter)) 
{ 
   // ...
} 
else 
{ 
   // ...
}

https://en.wikipedia.org/wiki/Defensive_programming might be an interesting read.