Need to let loose a primal scream without collecting footnotes first? Have a sneer percolating in your system but not enough time/energy to make a whole post about it? Go forth and be mid: Welcome to the Stubsack, your first port of call for learning fresh Awful you’ll near-instantly regret.
Any awful.systems sub may be subsneered in this subthread, techtakes or no.
If your sneer seems higher quality than you thought, feel free to cut’n’paste it into its own post — there’s no quota for posting and the bar really isn’t that high.
The post Xitter web has spawned soo many “esoteric” right wing freaks, but there’s no appropriate sneer-space for them. I’m talking redscare-ish, reality challenged “culture critics” who write about everything but understand nothing. I’m talking about reply-guys who make the same 6 tweets about the same 3 subjects. They’re inescapable at this point, yet I don’t see them mocked (as much as they should be)
Like, there was one dude a while back who insisted that women couldn’t be surgeons because they didn’t believe in the moon or in stars? I think each and every one of these guys is uniquely fucked up and if I can’t escape them, I would love to sneer at them.
(Credit and/or blame to David Gerard for starting this.)
i've heard about them before and got reminded of their existence against my will recently. (do you know that somebody made a recommendation engine for peertube? can you guess which CCC talk from last winter was on top of pile in their example?)
you know, i think they have a bit of that techbro urge to turn every human activity into series of marketable ESP32 IOT-enabled widgets, except that they don't do that to woo VCs, they say they do that for betterment of humanity, but i think they're doing it for clout. because lemmy has only communist programmers and no one else, not much later i stumbled upon an essay on how trying to make programming languages easier in some ways is doomed to fail, because the task of programming itself is complex and much more than just writing code, and if you try, you get monstrosities like COBOL. i'm not in IT but it seems to me that this take is more common among fans of C and has little overlap with type of techbros from above.
so in some way, they are trying to cobolify backyard chemistry. the thing that is stupid about it is that it has been done before, and it's a very useful tool, and also it does something completely opposite than what they wanted to do. it's called solid phase peptide synthesis, and it replaces synthetic process that previously has been used in liquid phase (that is, like you do usually in normal solutions in normal flasks). (there's also a way to make synthetic DNA/RNA in similar way. both have a limitation that only a certain number of aminoacids/bases is actually practical). the thing about SPPS is that it can be automated, and you can just type in sequence of a peptide you want to get, and machine handles part of the rest.
what you gotta give it to them is that automated synthesis allows for a rapid output of many compounds. but it's also hideously expensive, uses equally expensive reagents, and requires constant attention and maintenance from two, ideally more, highly trained professionals in order to keep it running, and even then syntheses still can fail. in order to figure out what got wrong you need to use analytical equipment that costs about as much as that first machine, and then you have to unfuck up that failed synthesis in the first place, which is something that non-chemist won't be able to do. and even when everything goes right, product is still dirty and has to be purified using some other equipment. and even when it works, scaleup requires completely different approach (the older one) because it just doesn't scale well above early phase research amounts.
what i meant to say is that while automation of this kind is good because it allows humans to skip mind-numbingly repetitive steps (and allows to focus on "the everything else" aspect of research, like experiment planning, or parts of synthesis that machine can't do - which tend to be harder and so more rewarding problems) this all absolutely does not lead to deskilling of synthesis like this bozo in camo vest wanted to, i'd say it's exactly the opposite. there's also the entire aspect of how they don't do analysis or purification of anything, and this alone i guess will kill people at some point
We must have watched different presentations; the one I watched was about producing hormone-replacement therapy for trans folks.
their original promise was that: you will be able to plug a jar to a controller, download instructions and it will make medicine for you, no knowledge of chemistry needed. i think it was one talk before this one where they claimed to make an antiviral (still under patent) and gave away some pills of it for free. i don't think they made it in a way that matters, they didn't show their pathway, they didn't show analyses they say they made, they don't say what they used as a starting material and how they got it, and they didn't provide anything in way of formulation or other three drugs needed in that treatment (iirc). it might be very well that their costs are even higher per pill than what usual distribution will charge, but they don't say any of that, and it might be just as possible that if more people did that starting material supply would dry out. (or they might be just lying) worse than that, while they might do some analyses, it's not included or expected in jar and controller scenario, so there's no real quality control and if released, this alone can be reasonably expected to kill people. i'm not sure if they even released anything workable in this capacity (they also claim that they made pyrimethamine, but it's also after nilered made it, so they might just copy his process. it's simpler thing)
what they're doing later: there's this horse medicine that you can use as (more dangerous, less effective) ersatz plan B, or this estradiol thing, it's much less sketchy because they don't cook anything, they "just" formulate an API they get from somewhere else, but it's still a fair bit sketchier than using fish antibiotics in humans because for example massive accidental overdose is still quite likely
Well, actually, Nurdrage was the synthesizer of pyrimethamine on Youtube (here is their playlist), and if one actually watches their videos then they will quickly learn that there are legal reasons why the synthesis pathway is so convoluted. We've discussed this before here and here. I agree that there's no substitute for spectrographic analysis.
Better not look up how much of the USA bans reproductive care for women and how many excess deaths that causes; hundreds of people/year already die from a lack of care and medicine.