Ask Lemmy

yeah, 100%. Not everybody gets gout, there is clearly a genetic profile that can develop gout... in the current metabolic context, and the modern diet.

People can't control their genetics, they can control their metabolism, and their diet.

Fructose has uric acid as a byproduct of its metabolism [86]. Fructose induced hyperuricemia has a pathogenetic role in metabolic syndrome [78,87]. Higher insulin concentrations, associated with metabolic syndrome, reduce the renal excretion of uric acid [47,80,88]. Uric acid is an inhibitor of nitric oxide synthase, [78] which is the catalyst for nitric oxide, critical for circulatory and immune homeostasis.

Reducing circulating uric acid concentrations is one of the mechanistic components of improved blood pressure control that is observed with a reduction in fructose intake [89].

• Except from https://doi.org/10.1016/C2019-0-03604-7 section 7.3 Pathophysiology of gout

Here are the references

• 47 - https://doi.org/10.1016/j.semnephrol.2011.08.004
• 78 - https://doi.org/10.3899/jrheum.170806
• 80 - https://doi.org/10.1186/1758-5996-4-12
• 86 - https://doi.org/10.1152/physrev.00019.2009
• 87 - https://doi.org/10.1152/ajprenal.00140.2005
• 88 - https://doi.org/10.1001/jama.1991.03470210076036
• 89 - https://doi.org/10.1093/ajh/hpaa044

All of that is to say elevated uric acid is not the root of the problem, its a symptom of the core problem.