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Methylated B vitamins and vitamin D were life changing discoveries. I have some polymorphisms (VDR and MTHFR) that mean I am less efficient at absorbing them from food. 2000 IU a day and a B-complex ended chronic depression/anxiety and insomnia for me. Those mutations are pretty common so I highly recommend trying them for anyone with similar issues.
Aside from that I think a whole foods plant based diet with some eggs and fish and no refined sugars is probably the way to go. Some micronutrients like vitamin A and K2 are more easily absorbed from animal sources, so eating a small amount of meat and/or eggs is probably a bit healthier than pure plant based IMO.
Research has shown that for the average person, vit D supplements are practically a waste as the forms they provide don't match what we need.
You and I are special cases.
Sun is what the typical person needs, so their body can produce the forms of D they need.
How do you know you have this? I got so much benefit from Nicotinamide Riboside, and after years of low vitamin D levels finally found one supplement that raised them, VeganD3+K2 - I'm not vegan but that is the one that has worked. Not sun (I get plenty of that) nor fish nor any other supplement ever got it out of the alleged critically low range.
If you have done a partial gene sequence for a service like ancestry or 23andme you can just look at the raw data and search for the known polymorphisms.
Oh, no I don't want to do that (have always felt uncomfortable about those). Thank you though, that makes sense.