Some background on this comic:
Transcript:
This is one of my personal favorites based mostly on one character's facial expression. The simple "gag" is that Indians and horses are meeting for the first time and handshakes are going all around. But it's the horse gesturing toward the scenery that I felt "made" this cartoon. I can't express it, but there's something captured there that I just like. If I had to draw it over again, the other characters could be drawn a myriad of ways—but I don't think I could ever replicate that one horse's expression.
Also, interesting that they edited it to change the width so much.
The artist has had a string of comics where the joke is pretty much just harassment. It worked out here because of the absurdity:
But mostly it's just been haha harassment:
So this is an iteration on that joke, where the humor is that it's the girl doing the harassment because it inverts expectations or something. TBH I think this artist is the weakest of the C&H artists and one of the reasons I've thought about switching to posting old comics randomly from across all the history instead of sequentially.