Several. I'll keep it to three.
One, was having to move out from my home state, twice. I have my fair share of criticism for some parts of it that I didn't like, like having been around some lowly leveled towns with druggies and drunks. But there have been an awful lot of ups as well, I love it's scenery, I love how it isn't billboard haven like the places I've moved to have had and I liked the small communities. As well as my state being a very progressive state too. If only it'd correct it's affordability problem, I would have loved to return there.
Two, the changing of the internet. I've been online for over 27 years now. It is depressing to watch it all devolve into a corporate marketing playground with so many subscriptions nagging you. I've had to watch so many good places shut down because of these increasing pressures of these changes affecting them. People I've known online, are either gone due to the sands of time or that they've passed away that I didn't realize until I get second or third hand information about it. It used to all be a rich and fulfilling experience. But every time I use the internet now, it feels shallower and shallower. If the internet were to suddenly up and vanish in maybe the next 5 minutes, I wouldn't complain. I'd just bow out and feel that we've done all that we've done.
Lastly, having to oust a friend of 5 years tenure for showing sympathy to pedophiles. They brought a lot of positivity and wholesomeness to my life during my time with them. We were even in a group with others that shared silliness and good times. But the past year it has been nothing but just senseless debates and one of which ended up them coming out as a pedo sympathizer which was something I just couldn't accept because of my experiences having been entangled with pedos and dealing with them and their illogical worldview on how they see minors.