this post was submitted on 15 Aug 2024
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If you have noticed a sudden accumulation of wrinkles, aches and pains or a general sensation of having grown older almost overnight, there may be a scientific explanation. Research suggests that rather than being a slow and steady process, aging occurs in at least two accelerated bursts.

The study, which tracked thousands of different molecules in people aged 25 to 75, detected two major waves of age-related changes at around ages 44 and again at 60. The findings could explain why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages.

“We’re not just changing gradually over time. There are some really dramatic changes,” said Prof Michael Snyder, a geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University and senior author of the study.

“It turns out the mid-40s is a time of dramatic change, as is the early 60s – and that’s true no matter what class of molecules you look at.”

...

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[–] solsangraal@lemmy.zip 86 points 3 months ago (2 children)

lol i turned 44 last year and yep. feel like shit all of a sudden

[–] Cheems@lemmy.world 10 points 3 months ago (1 children)

All of a sudden? You mean it gets worse??

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[–] Lexam@lemmy.ca 73 points 3 months ago (3 children)

I turn 44 on Saturday! Yay!

[–] xmunk@sh.itjust.works 52 points 3 months ago (1 children)
[–] HWK_290@lemmy.world 7 points 3 months ago (1 children)
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[–] RagingRobot@lemmy.world 12 points 3 months ago
[–] PickleRick@lemmy.world 5 points 3 months ago* (last edited 3 months ago) (1 children)

😢. It’s the guardian though so take it with a huge grain of bs.

[–] Landslide7648@discuss.tchncs.de 6 points 3 months ago

If only there was a way to look at the actual study, but oh no

[–] dactylotheca@suppo.fi 60 points 3 months ago

Fuck, that explains a lot

[–] NineMileTower@lemmy.world 46 points 3 months ago (5 children)

The research tracked 108 volunteers

Not enough to actually mean anything.

[–] fpslem@lemmy.world 49 points 3 months ago* (last edited 3 months ago) (1 children)

Read further in that paragraph:

Researchers assessed 135,000 different molecules (RNA, proteins and metabolites) and microbes (the bacteria, viruses and fungi living in the guts and on the skin of the participants).

Also, see the previous article in Nature linked in the article. That study looked at fewer proteins, but had over 4,000 participants.

[–] Webster@lemmy.world 31 points 3 months ago* (last edited 3 months ago)

I mean, that makes me even more skeptical. 108 volunteers tracked for that many sparesely populated vectors is 100% going to have hundreds of false positives just due to statistical noise.

[–] SoJB@lemmy.ml 19 points 3 months ago (5 children)

My favorite part of science discourse will always be people self-reporting how little they understand science the math behind statistics by complaining about sample sizes that have nothing wrong with them

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[–] ThrowawayPermanente@sh.itjust.works 43 points 3 months ago (5 children)

As a 41 year old, goddamnit

[–] chatokun@lemmy.dbzer0.com 28 points 3 months ago

43: chuckles, I'm in danger.

[–] Blum0108@lemmy.world 11 points 3 months ago

Lol literally my thought.

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[–] tiefling@lemmy.blahaj.zone 33 points 3 months ago (1 children)
[–] ripcord@lemmy.world 7 points 3 months ago

Oh man, 30 was the best.

Sorry to hear yours isn't.

[–] FlyingSquid@lemmy.world 33 points 3 months ago (1 children)

Well that explains why I feel like I'm about 80 now that I'm 47.

[–] Someonelol@lemmy.dbzer0.com 17 points 3 months ago (1 children)

Woah there, save something to degrade in another 13 years.

[–] FlyingSquid@lemmy.world 10 points 3 months ago

It's okay, my mom's in her 80s and my dad made it to his 80s and their parents all made it to their 90s, so I have a good 5-15 years to degrade once I turn 60.

[–] dezmd@lemmy.world 33 points 3 months ago (1 children)

Fuck you all, I just turned 44.

[–] ChickenLadyLovesLife@lemmy.world 32 points 3 months ago

44 is probably the average age at which people start paying for their kids' college tuitions. That shit will age anybody.

[–] IamSparticles@lemmy.zip 20 points 3 months ago (2 children)

My anecdotal confirmation is that I started having a lot more health issues in my mid 40s. My eyesight got a lot worse. I started having issues with high blood pressure and cholesterol. I'm about to turn 50 and things have mostly stabilized. Medication and more regular exercise helps. My eyes are still bad but they aren't getting worse as fast as they were.

[–] ChickenLadyLovesLife@lemmy.world 11 points 3 months ago (1 children)

I started playing Ultimate Frisbee again at 44 and quickly regained most of my youthful speed and jumping ability (and my tendency to huck). So for me it was like the opposite of this article's contention. Age 52/53 was a lot worse as that's when I started getting arthritis.

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[–] jordanlund@lemmy.world 6 points 3 months ago (1 children)
[–] PalmTreeIsBestTree@lemmy.world 7 points 3 months ago* (last edited 3 months ago)

Heart attack got my Dad at 48 ten years ago. If anyone has a preexisting heart condition like my father had, then you need to get checked up often or you might die sooner.

[–] DefiantBidet@lemmy.world 19 points 3 months ago (2 children)

48 here... i used to be able to read the freaking copyright date on those eye charts ... once i hit mid 40s i need glasses.

[–] FlyingSquid@lemmy.world 6 points 3 months ago (1 children)

I just got progressive bifocals. It was nice to be able to read my watch properly again, but not so nice to have to look down whenever I'm going up or down stairs and to have to move my head around all the time to see all the real estate on my monitor since it's 27".

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[–] Bishma@discuss.tchncs.de 4 points 3 months ago (1 children)

In less than 2 years (in my early 40s), my eyes went from better than 20/20 with great close up, to barely 20/20 with astigmatism and I need readers

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[–] ben_dover@lemmy.ml 17 points 3 months ago (3 children)

i thought becoming 30 fucked me up enough already... so i have to go through this two more times, only it will be worse? ugh...

[–] Senseless@feddit.org 6 points 3 months ago

I know what you mean. I make old people noises now, when I stand up from a low couch or sth.

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[–] TheGiantKorean@lemmy.world 16 points 3 months ago

I def feel like I noticed this in my mid 40s. My face and hair all looked very different within a year.

[–] dmtalon@infosec.pub 14 points 3 months ago (2 children)

Interestingly enough, a random couple things happened when I was between 43-44 that lead to me start distance running and run my first full marathon about 4 months before I turned 44.

I was decently fit before, but didn't run any distance above a maybe 5 miles. I do not remember anything negative happening around that time or shortly after. I was actually increasing my cardio endurance dramatically over the next 5 years or so.

[–] fpslem@lemmy.world 15 points 3 months ago (1 children)

Good on you, I've read elsewhere that the better shape you can be in prior to years of decline, the better you handle the natural aging process. I don't need to do anymore marathons, they're too hard on my knees, but running/biking and body-weight exercises are part of my attempt to stave off the inevitable.

[–] dmtalon@infosec.pub 6 points 3 months ago* (last edited 3 months ago) (1 children)

Oh ya... Marathons have come and gone for me :) Initially because they were just expensive but COVID had me WFH full time and the group I ran with was near my work office. So I sort of morphed into running alone and just as maintenance vs. Training for something.

I'm about to hit 53 and try to run between 15-20/miles a week still but I did fall behind on my fitness the end of last year when I had some crazy back spasms after sneezing (of all things) that really set me back. Takes forever to get back. Luckily I do not have any physical issues (knees etc) most if my issues now are not eating healthy enough and general motivation to improve. Sounds like I've got about 7 years to get on top of it so I can cruise through that age too :)

[–] fpslem@lemmy.world 7 points 3 months ago* (last edited 3 months ago) (1 children)

back spasms after sneezing (of all things)

This is the true humiliation of getting older. In my 20s I climbed mountains and had plenty of scrapes and mishaps, but I just shook them off and my body just healed up quickly. Now I can tweak my back with a sneeze or be sore for days just by raking leaves. Life comes at you fast.

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[–] Bishma@discuss.tchncs.de 11 points 3 months ago* (last edited 3 months ago) (6 children)

This article is reminding me of a study a few years back that suggested that (provided you're otherwise healthy and able bodied) you can get into any level or shape you want (if you put in the work of course) up until 60-something. Then you hit an age wall where about the best you can do is maintain what you've got. Suggesting that countering that 40-something aging event by pre-gaming for the 60-something aging is a smart plan.

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[–] nilaus@lemmy.world 12 points 3 months ago (3 children)

Turned 44 6 months ago. Haven't felt it yet. Guess it's going to get rough soon...

[–] GluWu@lemm.ee 8 points 3 months ago* (last edited 3 months ago) (1 children)

One morning you'll wake up and every bone in your body will pop simultaneously. Then while you lay there aching you'll let out a 6 mimutes and 20 second fart that doesn't have a happy ending.

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[–] PrimeMinisterKeyes@lemmy.world 5 points 3 months ago* (last edited 3 months ago)

Yeah West in his seminal "Scale" kind of corroborates the whole story.

It seems, though, that the molecular changes you are undergoing do not immediately translate into increased mortality, so you're going to have several more years of - presumably - feeling well until the big drop-off starts for all of us at about 60.
BTW, because of its wide range of topics, its solid scientific underpinnings and its excellent intellectual accessibility, this is one of two books I positively think should be taught at any school, the other one being Solé's "Phase Transitions."

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[–] demizerone@lemmy.world 8 points 3 months ago

Fucking great. I turn 44 next year.

[–] Sam_Bass@lemmy.world 8 points 3 months ago

Starting to believe it. Had a babyface for the first half of my life. Now i look like a retired state trooper

[–] moshankey@lemmy.world 8 points 3 months ago

Oh, fuck me! I got nothing else.

[–] Windex007@lemmy.world 6 points 3 months ago* (last edited 3 months ago)

The idea that anyone would think that our bodies change at a constant rate is so bizarre to me, having gone through puberty myself (not to brag).

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