I'm in a restricted country and my phone is not rooted, so if I use ad block apps like AdAway or Adgaurd they need to create a VPN connection in order to function unless the phone is rooted, and that VPN connection doesn't let me to enable another VPN in order to visit filtered websites or apps.
Ultimately, I think rooting is the way to go, but only if you have a device with a decent XDA thread guide and support. If you choose not to root, Adguard has their own VPN service integrated if you wanted to pay for that (haven't tried), or else you can add your own proxy servers through the app – so you can add individual server IPs for (say) Nord and connect to them while still using Adguard in VPN mode.