this post was submitted on 28 Aug 2024
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What makes you think they're mutated? There's a hint of mutation in the Spider Man origin story, as it's a radioactive spider, and radiation is associated with mutation. But, the rest of them get their powers in non-mutation-related ways.
Among many other things, like the Clone Saga clones having his powers, a Sentinel straight up scans Peter Parker and mistakes him for a mutant because his DNA has literal spider genes in it now. That's just Spidey canon.
Same with Super-soldier Serum that gave Rogers his power, it was a genetic modification and, eventually, the same is true of Weapon VI aka Luke Cage (Weapons Plus being a descendant program, he received a modified version of the Serum)
In Marvel comics there's generally a distinction between "mutants" and "mutates." A mutant got their powers from birth, typically from the X-gene, a mutate had something happen to them, but that's not a real scientific distinction. They've all been mutated. It's just in-universe discrimination and is often specifically portrayed as such. Like all discrimination, the distinction is quite often arbitrary and unjustified.