science

14848 readers

633 users here now

A community to post scientific articles, news, and civil discussion.

rule #1: be kind

<--- rules currently under construction, see current pinned post.

2024-11-11

founded 1 year ago

MODERATORS

m3t00@lemmy.world

Joleee@lemmy.world

laverabe@lemmy.world

DeadPand@midwest.social

221

Can THC Turn Back The Clock? Cannabis Reverses Brain Aging, Boosts Mental Capacity, New Study Suggests (www.benzinga.com)

submitted 3 months ago by karashta@lemm.ee to c/science@lemmy.world

80 comments fedilink hide all child comments

Initially, THC boosted brain metabolism and synaptic protein levels, indicative of heightened cognitive processes. Subsequently, it shifted towards reducing metabolic activities in the body akin to the effects seen with caloric restriction or intensive exercise, known for their anti-aging benefits.

you are viewing a single comment's thread
view the rest of the comments

[–] pbbananaman@lemmy.world 3 points 3 months ago (1 children)

Thanks this is a lot of great detail on the dosing mechanism that I think is really interesting. I love reading up on the experimental details and the actually components used to make these experiments work.

300mg of orally ingested THC spread out over 24 hours is about equivalent to consuming 1 typical candy/gummy every hour for 24 hours of the day. A reasonable or average or normal person would be uncomfortably high at these dosages. I also imagine the bioavailability of oral ingestion is less than the dosing mechanism you described although I’m not sure (is that getting taken up through the lymphatic system? How does it differ from oral ingestion or injection into the bloodstream?).

Fascinating stuff, thanks for sharing your knowledge.

[–] southsamurai@sh.itjust.works 1 points 3 months ago

Osmotic pumps tend to be equivalent to a transdermal patch in how the substance spreads through the body, but bypasses the need to go through skin. So, faster initially, but otherwise the dose over time would be the same, assuming the transdermal patch was able to maintain dosage (they aren't, there's a drop-off).

And, just as you said, the entire dose is taken in without any degradation by digestion, or being bound in something.

What I have zero clue about is what difference it would make in terms of numbers. It is equivalent in speed of uptake to subQ or IM injection, which is essentially immediate, just with a slight curve at the very beginning, so tiny it won't be noticeable to someone that experienced all those deliveries.

Vs IV, the initial release is slower with osmotic pumps, but the sustain of the pumps makes everything after that different.

Basically, the pump goes under the skin and leaks the substance into the intracellular fluids, to be taken up by capillaries into the bloodstream.