Rimworld

Design your base with "production near consumption" in mind and your pawns will spend less time doing the same tasks than they would otherwise. For example: crops near storage, storage near kitchen, kitchen near dining room.

It's fine if your bedrooms are slightly far away from the rest of the stuff. Your pawns should only walk it exactly twice a day.

It's useful to designate an area for raider corpses that is 1) roofed, 2) open (not a room), and 3) without flammable materials nearby. Then you can simply throw a Molotov there and get rid of the problem.

Human leather is poor clothing material, but it's great for armchairs.

Use armchairs everywhere that pawns spend a lot of time on. For example, in the front of production tables.

Keep spare shock lances, berserker lances, animal manhunter pulses. They'll save your day.

EMP against mechs.

If you must build out of wood, extend the roof two tiles over and then cut all plants below the roof. It works as a decent firebreaker.