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Had this conversation with someone who chose to no longer be at my table after meeting a blind NPC
(files.catbox.moe)
Another player who was at the table during the incident sent me this meme after the problem player in question (they had a history) left the group chat.
Felt like sharing it here because I'm sure more people should keep this kind of thing in mind.
It depends on the disability, the magic, and the DM's interpretation, I suppose. Lesser restoration is kind of a cure-all, gets rid of disease, poison, blindness, deafness, and paralysis, and 'disease' in particular might cover a pretty wide swath. Greater restoration can end effects that reduce ability scores or hit point maximums, which might include chronic conditions or congenital birth defects not directly linked to a disease. Regeneration can grow back missing body parts. Anything that these spells don't cover, Wish (and Divine Intervention) almost certainly would, but you'd be hard-pressed to find someone who could and would cast it.