“Alcohol is a mild poison” has been a house rule within my extended roleplaying circles for a long time. It fits well into almost any setting or metaphysics, and allows you to do interesting things with intoxication.
This comic follows on from the Previous comic which will almost certainly provide context.
You can follow this comic series from the start Here. Make sure to start at the bottom (oldest comic) and work upwards.
That relationship is why in every edition but fifth, healing is necromancy, and why Heal and Harm are identical in 3rd/pf, because they're the same fundamentally, you just had to tweak the settings on one to get the other.