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Thrive is a free, open-source game about the evolution of life.
(www.revolutionarygamesstudio.com)
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I guess both? You do hand-of-god design your own life form iteratively over generations, but other microorganisms evolve randomly and branch and die off all over the place (and your own species will branch off into other ones that randomly evolve too - you might be making a meal out of your cousins in a couple generations).