Strictly speaking about single player games, as in no rogue likes and such, Max Payne 2 is probably the game I played most times over the years.
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Stellaris, Rimworld, the Sims, and a lot of stragedy games.
I put multiple thousand hours into Mount blade warband, Crusader Kings 2, Europa universalis 4, and more.
X4 foundations and relevant DLC. I have multiple saves with over a year worth of playtime
The one I never get tired of replaying is Mafia 2. Maybe a weird choice since it's very linear and every play through is pretty much the same. But the story is just perfect for me. The gameplay perfectly suits the story, nothing especially clever, just well executed.
Then there's games like Binding of Isaac or Dead Cells where every play through is different.
Red Dead Redemption 2, Fallout 4, the BioShock series
Just Cause 3, with the additional DLC. I've been through all of it three full times, slowly plugging through a fourth (when time allows)
I was about to suggest "Balatro" but you don't want infinite dopamine game then play The Binding of Isaac:Rebirth.
Football Manager 2016 was the first version I tried. I put 1,500+ hours into it and only stopped because I decided to upgrade to Football Manager 2018. I'm on 2024 now at ~400 hours.
Heroes of Might and Magic - the originals. Mostly 3, but any from 1 to 5 can do it.
6 and upwards, it's just pure Ubisoft enshitification. Can't even play them properly anymore due to the online component having shutdown its service.
I’ve played Risk of Rain 2 on and off for years and I’m not bored of it yet
I feel like the best options would be strategy such as CK3 as the other commenter mentioned or endless sandbox games like Minecraft and Euro/American Truck Simulator. X4 Foundations is a pretty fun space sim, and there are the Bethesda games with mods, Skyrim and Fallout 4 have some pretty cool mods and eventually Starfield too.
I want to throw out Mario Bro 3, Tetris, Dr Mario, and Sonic Mania. Just pick up and go, no long term commitment, always fun solo but you can add a friend anytime. Simple but rewarding game play loop.
I have enjoyed caves of qud. Feels like every run is brand new.
My most played games outside of actually multiplayer games are arpgs. Diablo(mostly 2 and 3), path of exile, last epoch. Diablo2 and last epoch can be played offline, PoE can't. And yes, they're technically online multiplayer games but most people play them alone so they might as well be single player games to me. After that my most played games are RPGs and rogue likes. Plenty of good suggestions for that already
Wart Under